PFIC Voices: “In PFIC, the symptoms of the disease are often worse than the disease itself.”

Progressive familial intrahepatic cholestasis (PFIC) is a rare and progressive liver disease. Professor Richard Thompson is a Pediatric Hepatologist at King’s College Hospital and Professor of Molecular Hepatology at King’s College London, England. He is a consultant to Albireo and one of the world’s leading experts in rare cholestatic liver conditions, and treats patients living with rare disease progressive familial intrahepatic cholestasis.

WARNING: Video contains graphic images that may be disturbing or alarming to some viewers.

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The impact of rare liver disease PFIC can be profound. Professor Richard Thompson diagnoses and manages patients with PFIC and has observed that “the symptoms of the disease are often worse than the disease itself.” Consequences of PFIC include intractable pruritus, and children experience failure to thrive, are often deprived of sleep, and may be unable to focus in school. Learn more about PFIC from a healthcare provider’s perspective in this 7-minute video.

// VIDEO CHAPTERS //

00:15 Progressive Familial Intrahepatic Cholestasis (PFIC), a group of conditions that present in a similar way
00:43 What are bile salts? The role of bile salts in breaking down lipids in our body
1:45 What happens when bile salts are not excreted normally? How may abnormal bile salt excretion lead to complications?
2:40 Pruritus management may dictate quality of life for patients with PFIC
3:10 What is pruritus?
4:05 Partial external biliary diversion is a surgical option to help remove bile acids
5:00 Importance of patient advocacy groups to support PFIC community
5:45 Mandate for the future is driven by need to support patients and families

// MORE PFIC RESOURCES //
Children’s Liver Disease Foundation (UK):
American Liver Foundation: www.liverfoundation.org
PFIC Advocacy and Resource Network: www.PFIC.org
PEDFIC Clinical Trial Program:

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